Biodegradable Chitosan-graft-Poly(l-lactide) Copolymers For Bone Tissue Engineering
نویسندگان
چکیده
منابع مشابه
Chitosan/poly(DL,lactide-co-glycolide) scaffolds for tissue engineering.
Chitosan/poly(DL-lactide-co-glycolide) (Ch/DL PLG) composite scaffolds were fabricated by freeze-drying lyophilization, and were evaluated and compared for use as a bone regeneration scaffold through measurements of the compression mechanical properties of the porous scaffolds. Also, In vitro cell culture of Sprague-Dawley rat's osteoblasts were used to evaluate the phenotype expression of cell...
متن کاملBiodegradable Polymers for Bone Tissue Engineering
The destruction of bone tissue due to disease (osteonecrosis, tumors, osteoporosis) or inefficient healing posttraumatic injury is a problem affecting the world population. The repair of small defect may be mediated by the osteoblast and osteoclast activity which ensures a balanced control of bone resorption and formation, allowing the bone repair, renewal, and growth. However, when the defect ...
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Both chitosan and polylactide/polyglycolide have good biocompatibility and can be used to produce tissue engineering scaffolds for cultured cells. However the synthetic scaffolds lack groups that would facilitate their modification, whereas chitosan has extensive active amide and hydroxyl groups which would allow it to be subsequently modified for the attachment of peptides, proteins and drugs....
متن کاملIn vitro evaluation of photo-crosslinkable chitosan-lactide hydrogels for bone tissue engineering.
Here we report the development and characterization of novel photo-crosslinkable chitosan-lactide (Ch-LA) hydrogels for bone tissue engineering. We synthesized the hydrogels based on Ch, LA, and methacrylic anhydride (MA), and examined their chemical structures, degradation rates, compressive moduli, and protein release kinetics. We also evaluated the cytotoxicity of the hydrogels and delivery ...
متن کاملBiodegradable Polymers in Bone Tissue Engineering
The use of degradable polymers in medicine largely started around the mid 20 century with their initial use as in vivo resorbing sutures. Thorough knowledge on this topic as been gained since then and the potential applications for these polymers were, and still are, rapidly expanding. After improving the properties of lactic acid-based polymers, these were no longer studied only from a scienti...
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ژورنال
عنوان ژورنال: Polymers
سال: 2020
ISSN: 2073-4360
DOI: 10.3390/polym12020316